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Anti-HIV vaccine
By Johnson
Anti-HIV vaccine
The vaccine is made from a patient's own dendrites cells and isolated from the patient's own blood. Dendritic cells are crucial to the immune response. They grab foreign bodies in the blood and present them to other immune cells to trigger powerful immune system responses to destroy the foreign invaders. Vaccines stimulate the body’s immune system to provide protection against infection or disease. Vaccines against are being developed, and they are in various stages of clinical trial but at present none have proven effective.
It is important to conduct research to find an effective vaccine because:
The availability of a safe, highly effective and accessible preventive vaccine would be a valuable complement to other preventive interventions, significantly contributing to the interruption of the chain of transmission of HIV.
Well conceived immunization strategies could reach populations where other interventions are not sufficiently effective.
Research on preventive vaccines is providing new information on the possible use of vaccines as therapeutic interventions, to be used in association with antiretroviral therapies, which could lead to a lowering in the cost of the treatments and to an increase on their long-term efficacy.
The essence of traditional vaccine technology is to make a disease-causing microbe detectable by the immune system. The easiest means is to present a disabled or killed version that awakens this immunity. Once that's accomplished, a scientist can stand back and let the body take over.
However, HIV, the virus that causes AIDS, is so changeable that such an approach hasn't worked. As an alternative, researchers are using a glycoprotein found on the surface of HIV--not the virus itself--as a red flag for the immune system. A vaccine is a substance that is introduced into the body to prevent infection or to control disease due to a certain pathogen (any disease-causing organism, such as a virus, bacteria or parasite); the vaccine 'teaches' the body how to defend itself against a pathogen by creating an immune response .Vaccines can be introduced in different ways, such as injection into the muscle (intramuscular) or under the skin (intradermal or subcutaneous); by application to the skin (transdermal);by application to the inside of the nose(nasal);or by being swallowed (oral). Right now there is no vaccine to protect against HIV/AIDS.
A vaccine's efficacy refers to how well it protects against disease or infection when it is tested in a large trial in humans; a vaccine's effectiveness
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refers to how well it reduces the amount of disease once it is used in the overall population.
HIV infection normally turns these important immune system responses off. But animal studies show that when dendritic cells are "loaded" with whole, killed AIDS viruses, they can trigger effective immune responses that keep infected animals from dying of AIDS. Vaccines could be a promising strategy for treating people with chronic infection," Andrieu and colleagues write. "The significant decrease of viral load as well as maintenance of ... [T-]cell counts observed at one year after immunization are particularly promising."
The researchers warn that their study is only proof of principle. It's still not clear which patients do best with the vaccine, although there's evidence that vaccination should be given as soon after infection as possible. Only clinical trials comparing people who get the vaccine to those who don't can show whether this vaccine really is an effective AIDS therapy. Other experimental vaccines made of viruses carrying foreign genes tend to slay the cells they invade. This rabies virus doesn't kill the cells it takes over, Schnell says. Thus, he says, "there's a better chance that the glycoprotein, after infection, will be expressed in the cell.
Human immunodeficiency virus (HIV) attacks human immune system and causes AIDS. finds and destroys a type of white blood cell (T cells or CD4 cells) that the immune system must have to fight disease. AIDS stands for acquired immunodeficiency syndrome. AIDS is the final stage of infection. Having AIDS means that the virus has weakened the immune system to the point at which the body has a difficult time fighting infections. There are three main types of test: antibody test, antigen test, PCR test. The standard test looks for antibodies in a person's blood. The antigen on that most commonly provokes an antibody response is the protein P24. P24 antigen tests are sometimes used to screen donated blood, but they can also be used for testing for in individuals, as they can detect.
HIV P24 test detects earlier than standard antibody tests. Some of the most modern tests combine P24 and other antigen tests with standard antibody identification methods to enable earlier and more accurate detection. The recombinant antigens provided by Hotgen include gp41, gp36 and gp41+36, all of which have been proved by IVD regnant companies to have high activity.
Keywords: HIV,AIDS,HIV Cure,HIV Treatment,HIV Infection,HIV Dating,HIV Positive,HIV Symptoms.
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